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April 2012
- Six miners in Yunnan hospitalised with symptoms very similar to a SARS-CoV-2 infection after catching coronavirus strain RaTG13/CoV4991. Three miners died. Wuhan Institute of Virology researchers collected tissue samples, and later visited the caves to acquire more material.
October 2014
- US government funding of gain-of-function research that makes viruses more dangerous, pending further risk assessment.
November 2015
- Research into a lab-made coronavirus related to SARS-CoV debate over whether the pandemic potential was worth the risk.
December 2017
- NIH funding of Gain-of-Function research.
March 2018
- EcoHealth Alliance submits proposal to DARPA to insert furin cleavage sites into SARS-CoV viruses to more efficiently bind to human cells
